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Article

Origin recognition complex (ORC) in transcriptional silencing and DNA replication in S. cerevisiae.

Science (New York, N.Y.) - 17 Dec 1993

Foss M, McNally F J, Laurenson P, Rine J

Abstract excerpt

In Saccharomyces cerevisiae, the HMR-E silencer blocks site-specific interactions between proteins and their recognition sequences in the vicinity of the silencer. Silencer function is correlated with the firing of an origin of replication at HMR-E. An essential gene with a role in transcriptional silencing was identified by means of a screen for mutations affecting expression of HMR. This gene, known as ORC2,...

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Source

Identifiers

PMID: 8266071
DOI: 10.1126/science.8266071

Genes

ORC2

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Origin recognition complex (ORC) in transcriptional silencing and DNA replication in S. cerevisiae.PMID 8266071Read ↗

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The origin recognition complex has essential functions in transcriptional silencing and chromosomal replication.Semantic proximity Read ↗

The role of Sas2, an acetyltransferase homologue of Saccharomyces cerevisiae, in silencing and ORC function.Semantic proximity Read ↗

Tolerance of Sir1p/origin recognition complex-dependent silencing for enhanced origin firing at HMRa.Semantic proximity Read ↗

Role of interactions between the origin recognition complex and SIR1 in transcriptional silencing.Semantic proximity Read ↗

Separable functions of ORC5 in replication initiation and silencing in Saccharomyces cerevisiae.Semantic proximity Read ↗

Separation of origin recognition complex functions by cross-species complementation.Semantic proximity Read ↗

The origin recognition complex in silencing, cell cycle progression, and DNA replication.Semantic proximity Read ↗

Characterization of an essential Orc2p-associated factor that plays a role in DNA replication.Semantic proximity Read ↗

A role for the replication proteins PCNA, RF-C, polymerase epsilon and Cdc45 in transcriptional silencing in Saccharomyces cerevisiae.Semantic proximity Read ↗

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