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Article

Role of interactions between the origin recognition complex and SIR1 in transcriptional silencing.

Nature - 16 May 1996

Triolo T, Sternglanz R

Abstract excerpt

Transcriptional silencing of the HM mating-type loci in the yeast Saccharomyces cerevisiae is caused by the localized formation of an altered chromatin structure, analogous to heterochromatin in higher eukaryotes. Silencing depends on cis-acting sequences, termed silencers, as well as several trans-acting factors, including histones H4 and H3, proteins RAP1 and ABF1, and the four SIR proteins (SIR1-4). Each of...

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Source

Identifiers

PMID: 8622770
DOI: 10.1038/381251a0

Genes

ORC1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Research trail→

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Role of interactions between the origin recognition complex and SIR1 in transcriptional silencing.PMID 8622770Read ↗

Yeast origin recognition complex is involved in DNA replication and transcriptional silencing.Semantic proximity Read ↗

The role of Sas2, an acetyltransferase homologue of Saccharomyces cerevisiae, in silencing and ORC function.Semantic proximity Read ↗

Elaboration, diversification and regulation of the Sir1 family of silencing proteins in Saccharomyces.Semantic proximity Read ↗

Control of replication initiation and heterochromatin formation in Saccharomyces cerevisiae by a regulator of meiotic gene expression.Semantic proximity Read ↗

A region of the Sir1 protein dedicated to recognition of a silencer and required for interaction with the Orc1 protein in saccharomyces cerevisiae.Semantic proximity Read ↗

Positive roles of SAS2 in DNA replication and transcriptional silencing in yeast.Semantic proximity Read ↗

Origin recognition complex (ORC) in transcriptional silencing and DNA replication in S. cerevisiae.Semantic proximity Read ↗

Phylogenetic conservation and homology modeling help reveal a novel domain within the budding yeast heterochromatin protein Sir1.Semantic proximity Read ↗

Separation of transcriptional activation and silencing functions of the RAP1-encoded repressor/activator protein 1: isolation of viable mutants affecting both silencing and telomere length.Semantic proximity Read ↗

Silencing and heritable domains of gene expression.Semantic proximity Read ↗

SAS4 and SAS5 are locus-specific regulators of silencing in Saccharomyces cerevisiae.Semantic proximity Read ↗

Disturbance of normal cell cycle progression enhances the establishment of transcriptional silencing in Saccharomyces cerevisiae.Semantic proximity Read ↗

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