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Article

Role of interactions between the origin recognition complex and SIR1 in transcriptional silencing.

Nature - 16 May 1996

Triolo T, Sternglanz R

Abstract excerpt

Transcriptional silencing of the HM mating-type loci in the yeast Saccharomyces cerevisiae is caused by the localized formation of an altered chromatin structure, analogous to heterochromatin in higher eukaryotes. Silencing depends on cis-acting sequences, termed silencers, as well as several tra...

Topics

DNA, Fungal
DNA-Binding Proteins
Fungal Proteins
Gene Expression Regulation, Fungal
Histone Deacetylases
Models, Genetic
Mutation
Protein Binding
Recombinant Fusion Proteins
Replication Origin
Saccharomyces cerevisiae
Silent Information Regulator Proteins, Saccharomyces cerevisiae

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Sirtuin 2

Sirtuins

Trans-Activators

Transcription, Genetic

Source

Identifiers

PMID: 8622770
DOI: 10.1038/381251a0

Genes

ORC1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-8622770-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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Role of interactions between the origin recognition complex and SIR1 in transcriptional silencing.PMID 8622770Read ↗

Yeast origin recognition complex is involved in DNA replication and transcriptional silencing.Semantic proximity Read ↗

The role of Sas2, an acetyltransferase homologue of Saccharomyces cerevisiae, in silencing and ORC function.Semantic proximity Read ↗

Elaboration, diversification and regulation of the Sir1 family of silencing proteins in Saccharomyces.Semantic proximity Read ↗

Control of replication initiation and heterochromatin formation in Saccharomyces cerevisiae by a regulator of meiotic gene expression.Semantic proximity Read ↗

A region of the Sir1 protein dedicated to recognition of a silencer and required for interaction with the Orc1 protein in saccharomyces cerevisiae.Semantic proximity Read ↗

Positive roles of SAS2 in DNA replication and transcriptional silencing in yeast.Semantic proximity Read ↗

Origin recognition complex (ORC) in transcriptional silencing and DNA replication in S. cerevisiae.Semantic proximity Read ↗

Phylogenetic conservation and homology modeling help reveal a novel domain within the budding yeast heterochromatin protein Sir1.Semantic proximity Read ↗

Separation of transcriptional activation and silencing functions of the RAP1-encoded repressor/activator protein 1: isolation of viable mutants affecting both silencing and telomere length.Semantic proximity Read ↗

Silencing and heritable domains of gene expression.Semantic proximity Read ↗

SAS4 and SAS5 are locus-specific regulators of silencing in Saccharomyces cerevisiae.Semantic proximity Read ↗

Disturbance of normal cell cycle progression enhances the establishment of transcriptional silencing in Saccharomyces cerevisiae.Semantic proximity Read ↗

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