Set2-catalyzed methylation of histone H3 represses basal expression of GAL4 in Saccharomyces cerevisiae.

doi:10.1128/MCB.23.17.5972-5978.2003

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Article

Set2-catalyzed methylation of histone H3 represses basal expression of GAL4 in Saccharomyces cerevisiae.

Molecular and cellular biology - 1 Sept 2003

Landry Joseph, Sutton Ann, Hesman Tina, Min Jinrong, Xu Rui-Ming, Johnston Mark, Sternglanz Rolf

Abstract excerpt

Recent work has shown that histone methylation is an important regulator of transcription. While much is known about the roles of histone methyltransferases (HMTs) in the establishment of heterochromatin, little is known of their roles in the regulation of actively transcribed genes. We describe an in vivo role of the Saccharomyces cerevisiae HMT, Set2. We identified SET2 as a gene necessary for repression of...

Topics

Amino Acid Sequence
Base Sequence
Catalytic Domain
DNA-Binding Proteins
Gene Expression Regulation, Fungal
Histones
Lysine
Methylation
Methyltransferases
Molecular Sequence Data

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Mutation

Protein Structure, Tertiary

Repressor Proteins

Saccharomyces cerevisiae

Saccharomyces cerevisiae Proteins

Sequence Homology, Amino Acid

Transcription Factors

Transcription, Genetic

Source

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Identifiers

PMID: 12917322
DOI: 10.1128/MCB.23.17.5972-5978.2003
PMCID: PMC180946

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-12917322-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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Set2-catalyzed methylation of histone H3 represses basal expression of GAL4 in Saccharomyces cerevisiae.PMID 12917322Read ↗

Histone H3 K36 methylation is mediated by a trans-histone methylation pathway involving an interaction between Set2 and histone H4.Semantic proximity Read ↗

A conserved genetic interaction between Spt6 and Set2 regulates H3K36 methylation.Semantic proximity Read ↗

A trithorax-group complex purified from Saccharomyces cerevisiae is required for methylation of histone H3.Semantic proximity Read ↗

NuA4 links methylation of histone H3 lysines 4 and 36 to acetylation of histones H4 and H3.Semantic proximity Read ↗

Evidence that Set1, a factor required for methylation of histone H3, regulates rDNA silencing in S. cerevisiae by a Sir2-independent mechanism.Semantic proximity Read ↗

The BUR1 cyclin-dependent protein kinase is required for the normal pattern of histone methylation by SET2.Semantic proximity Read ↗

The Set2 histone methyltransferase functions through the phosphorylated carboxyl-terminal domain of RNA polymerase II.Semantic proximity Read ↗

Histone H3 lysine 36 dimethylation (H3K36me2) is sufficient to recruit the Rpd3s histone deacetylase complex and to repress spurious transcription.Semantic proximity Read ↗

Histone H3 lysine 4 methylation is mediated by Set1 and required for cell growth and rDNA silencing in Saccharomyces cerevisiae.Semantic proximity Read ↗

Catalytic and functional roles of conserved amino acids in the SET domain of the S. cerevisiae lysine methyltransferase Set1.Semantic proximity Read ↗

A nucleosome surface formed by histone H4, H2A, and H3 residues is needed for proper histone H3 Lys36 methylation, histone acetylation, and repression of cryptic transcription.Semantic proximity Read ↗

A comprehensive library of histone mutants identifies nucleosomal residues required for H3K4 methylation.Semantic proximity Read ↗

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