SAS4 and SAS5 are locus-specific regulators of silencing in Saccharomyces cerevisiae.

doi:10.1093/genetics/153.1.25

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Article

SAS4 and SAS5 are locus-specific regulators of silencing in Saccharomyces cerevisiae.

Genetics - 1 Sept 1999

Xu E Y, Kim S, Rivier D H

Abstract excerpt

Sir2p, Sir3p, Sir4p, and the core histones form a repressive chromatin structure that silences transcription in the regions near telomeres and at the HML and HMR cryptic mating-type loci in Saccharomyces cerevisiae. Null alleles of SAS4 and SAS5 suppress silencing defects at HMR; therefore, SAS4 and SAS5 are negative regulators of silencing at HMR. This study revealed that SAS4 and SAS5 contribute to silencing at...

Topics

Alleles
Chromatin
Fungal Proteins
Gene Deletion
Gene Dosage
Gene Expression Regulation, Fungal
Genes, Fungal
Genes, Mating Type, Fungal
Models, Genetic
Phenotype
Repressor Proteins
Response Elements
Saccharomyces cerevisiae
Silent Information Regulator Proteins, Saccharomyces cerevisiae
Suppression, Genetic
Telomere
Trans-Activators

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Identifiers

PMID: 10471697
DOI: 10.1093/genetics/153.1.25
PMCID: PMC1460757

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