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Article

SAS4 and SAS5 are locus-specific regulators of silencing in Saccharomyces cerevisiae.

Genetics - 1 Sept 1999

Xu E Y, Kim S, Rivier D H

Abstract excerpt

Sir2p, Sir3p, Sir4p, and the core histones form a repressive chromatin structure that silences transcription in the regions near telomeres and at the HML and HMR cryptic mating-type loci in Saccharomyces cerevisiae. Null alleles of SAS4 and SAS5 suppress silencing defects at HMR; therefore, SAS4 and SAS5 are negative regulators of silencing at HMR. This study revealed that SAS4 and SAS5 contribute to silencing at...

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Identifiers

PMID: 10471697
DOI: 10.1093/genetics/153.1.25
PMCID: PMC1460757

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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SAS4 and SAS5 are locus-specific regulators of silencing in Saccharomyces cerevisiae.PMID 10471697Read ↗

Identification of SAS4 and SAS5, two genes that regulate silencing in Saccharomyces cerevisiae.Semantic proximity Read ↗

Two classes of sir3 mutants enhance the sir1 mutant mating defect and abolish telomeric silencing in Saccharomyces cerevisiae.Semantic proximity Read ↗

A region of the nucleosome required for multiple types of transcriptional silencing in Saccharomyces cerevisiae.Semantic proximity Read ↗

Identification of a novel allele of SIR3 defective in the maintenance, but not the establishment, of silencing in Saccharomyces cerevisiae.Semantic proximity Read ↗

The role of Sas2, an acetyltransferase homologue of Saccharomyces cerevisiae, in silencing and ORC function.Semantic proximity Read ↗

Elaboration, diversification and regulation of the Sir1 family of silencing proteins in Saccharomyces.Semantic proximity Read ↗

Locus specificity determinants in the multifunctional yeast silencing protein Sir2.Semantic proximity Read ↗

A histone variant, Htz1p, and a Sir1p-like protein, Esc2p, mediate silencing at HMR.Semantic proximity Read ↗

Hyperactivation of the silencing proteins, Sir2p and Sir3p, causes chromosome loss.Semantic proximity Read ↗

The SIR2 gene family, conserved from bacteria to humans, functions in silencing, cell cycle progression, and chromosome stability.Semantic proximity Read ↗

Structural analyses of Sum1-1p-dependent transcriptionally silent chromatin in Saccharomyces cerevisiae.Semantic proximity Read ↗

Role of interactions between the origin recognition complex and SIR1 in transcriptional silencing.Semantic proximity Read ↗

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