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Article

Dependence of ORC silencing function on NatA-mediated Nalpha acetylation in Saccharomyces cerevisiae.

Molecular and cellular biology - 1 Dec 2004

Geissenhöner Antje, Weise Christoph, Ehrenhofer-Murray Ann E

Abstract excerpt

N(alpha) acetylation is one of the most abundant protein modifications in eukaryotes and is catalyzed by N-terminal acetyltransferases (NATs). NatA, the major NAT in Saccharomyces cerevisiae, consists of the subunits Nat1p, Ard1p, and Nat5p and is necessary for the assembly of repressive chromatin structures. Here, we found that Orc1p, the large subunit of the origin recognition complex (ORC), required NatA...

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Identifiers

PMID: 15542839
DOI: 10.1128/MCB.24.23.10300-10312.2004
PMCID: PMC529049

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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