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Article

Regulation of Telomere Length Requires a Conserved N-Terminal Domain of Rif2 in Saccharomyces cerevisiae.

Genetics - 1 Oct 2015

Kaizer Hannah, Connelly Carla J, Bettridge Kelsey, Viggiani Christopher, Greider Carol W

Abstract excerpt

The regulation of telomere length equilibrium is essential for cell growth and survival since critically short telomeres signal DNA damage and cell cycle arrest. While the broad principles of length regulation are well established, the molecular mechanism of how these steps occur is not fully understood. We mutagenized the RIF2 gene in Saccharomyces cerevisiae to understand how this protein blocks excess telomere...

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Identifiers

PMID: 26294668
DOI: 10.1534/genetics.115.177899
PMCID: PMC4596670

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Research trail→

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Regulation of Telomere Length Requires a Conserved N-Terminal Domain of Rif2 in Saccharomyces cerevisiae.PMID 26294668Read ↗

Regulation of telomere length by an N-terminal region of the yeast telomerase reverse transcriptase.Semantic proximity Read ↗

A novel Rap1p-interacting factor, Rif2p, cooperates with Rif1p to regulate telomere length in Saccharomyces cerevisiae.Semantic proximity Read ↗

Rif2 promotes a telomere fold-back structure through Rpd3L recruitment in budding yeast.Semantic proximity Read ↗

Mutational analysis defines a C-terminal tail domain of RAP1 essential for Telomeric silencing in Saccharomyces cerevisiae.Semantic proximity Read ↗

C-terminal truncation of RAP1 results in the deregulation of telomere size, stability, and function in Saccharomyces cerevisiae.Semantic proximity Read ↗

Telomere length homeostasis is achieved via a switch between telomerase- extendible and -nonextendible states.Semantic proximity Read ↗

Telomerase, the recombination machinery and Rap1 play redundant roles in yeast telomere protection.Semantic proximity Read ↗

Inherited long telomeres induce a genome-wide transcriptional response in budding yeastSemantic proximity Read ↗

Depleting components of the THO complex causes increased telomere length by reducing the expression of the telomere-associated protein Rif1p.Semantic proximity Read ↗

Rif1 and Exo1 regulate the genomic instability following telomere losses.Semantic proximity Read ↗

Reduced Rif2 and lack of Mec1 target short telomeres for elongation rather than double-strand break repair.Semantic proximity Read ↗

Rif1: A Conserved Regulator of DNA Replication and Repair Hijacked by Telomeres in YeastsSemantic proximity Read ↗

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