Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Rif1 acts through Protein Phosphatase 1 but independent of replication timing to suppress telomere extension in budding yeast.

Nucleic acids research - 4 May 2018

Kedziora Sylwia, Gali Vamsi K, Wilson Rosemary H C, Clark Kate R M, Nieduszynski Conrad A, Hiraga Shin-Ichiro, Donaldson Anne D

Abstract excerpt

The Rif1 protein negatively regulates telomeric TG repeat length in the budding yeast Saccharomyces cerevisiae, but how it prevents telomere over-extension is unknown. Rif1 was recently shown to control DNA replication by acting as a Protein Phosphatase 1 (PP1)-targeting subunit. Therefore, we investigated whether Rif1 controls telomere length by targeting PP1 activity. We find that a Rif1 mutant defective for...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Intracellular Signaling Peptides and Proteins
Share to Protein Phosphatase 1

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Protein Serine-Threonine Kinases

Share to Replication Origin

Share to Repressor Proteins

Share to Telomere

Share to Telomere-Binding Proteins

Share to Telomere Homeostasis

Source

Open in PubMed Open full text

Identifiers

PMID: 29529242
DOI: 10.1093/nar/gky132
PMCID: PMC5934629

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Rif1 acts through Protein Phosphatase 1 but independent of replication timing to suppress telomere extension in budding yeast.PMID 29529242Read ↗

At short telomeres Tel1 directs early replication and phosphorylates Rif1.Semantic proximity Read ↗

The role of Rif1 in telomere length regulation is separable from its role in origin firing.Semantic proximity Read ↗

Rif1: A Conserved Regulator of DNA Replication and Repair Hijacked by Telomeres in YeastsSemantic proximity Read ↗

A novel Rap1p-interacting factor, Rif2p, cooperates with Rif1p to regulate telomere length in Saccharomyces cerevisiae.Semantic proximity Read ↗

Budding yeast Rif1 binds to replication origins and protects DNA at blocked replication forks.Semantic proximity Read ↗

Rif1 controls DNA replication by directing Protein Phosphatase 1 to reverse Cdc7-mediated phosphorylation of the MCM complex.Semantic proximity Read ↗

Rif1 Regulates the Fate of DNA Entanglements during MitosisSemantic proximity Read ↗

Taz1, Rap1 and Rif1 act both interdependently and independently to maintain telomeres.Semantic proximity Read ↗

Depleting components of the THO complex causes increased telomere length by reducing the expression of the telomere-associated protein Rif1p.Semantic proximity Read ↗

Budding yeast Rap1, but not telomeric DNA, is inhibitory for multiple stages of DNA replication in vitroSemantic proximity Read ↗

Telomerase is essential to alleviate pif1-induced replication stress at telomeres.Semantic proximity Read ↗

Human Rif1 protein binds aberrant telomeres and aligns along anaphase midzone microtubulesSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.