Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Involvement of the silencer and UAS binding protein RAP1 in regulation of telomere length.

Science (New York, N.Y.) - 26 Oct 1990

Lustig A J, Kurtz S, Shore D

Abstract excerpt

The yeast protein RAP1, initially described as a transcriptional regulator, binds in vitro to sequences found in a number of seemingly unrelated genomic loci. These include the silencers at the transcriptionally repressed mating-type genes, the promoters of many genes important for cell growth, and the poly[(cytosine)1-3 adenine] [poly(C1-3A)] repeats of telomeres. Because RAP1 binds in vitro to the poly(C1-3A)...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Base Sequence
Share to Binding Sites
Share to DNA-Binding Proteins

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Genes, Fungal

Share to Molecular Sequence Data

Share to Mutation

Share to Plasmids

Share to Saccharomyces cerevisiae

Source

Identifiers

PMID: 2237406
DOI: 10.1126/science.2237406

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Involvement of the silencer and UAS binding protein RAP1 in regulation of telomere length.PMID 2237406Read ↗

A RAP1-interacting protein involved in transcriptional silencing and telomere length regulation.Semantic proximity Read ↗

C-terminal truncation of RAP1 results in the deregulation of telomere size, stability, and function in Saccharomyces cerevisiae.Semantic proximity Read ↗

Separation of transcriptional activation and silencing functions of the RAP1-encoded repressor/activator protein 1: isolation of viable mutants affecting both silencing and telomere length.Semantic proximity Read ↗

A novel Rap1p-interacting factor, Rif2p, cooperates with Rif1p to regulate telomere length in Saccharomyces cerevisiae.Semantic proximity Read ↗

RAP1 protein activates and silences transcription of mating-type genes in yeast.Semantic proximity Read ↗

Evidence that a complex of SIR proteins interacts with the silencer and telomere-binding protein RAP1.Semantic proximity Read ↗

Yeast Rap1 contributes to genomic integrity by activating DNA damage repair genes.Semantic proximity Read ↗

A protein-counting mechanism for telomere length regulation in yeast.Semantic proximity Read ↗

Genetic analysis of Rap1p/Sir3p interactions in telomeric and HML silencing in Saccharomyces cerevisiae.Semantic proximity Read ↗

Mutational analysis defines a C-terminal tail domain of RAP1 essential for Telomeric silencing in Saccharomyces cerevisiae.Semantic proximity Read ↗

A conserved motif within RAP1 has diversified roles in telomere protection and regulation in different organisms.Semantic proximity Read ↗

SIR3 and SIR4 proteins are required for the positioning and integrity of yeast telomeres.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.