Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Genetic analysis of Rap1p/Sir3p interactions in telomeric and HML silencing in Saccharomyces cerevisiae.

Genetics - 1 May 1996

Liu C, Lustig A J

Abstract excerpt

We have identified three SIR3 suppressors of the telomeric silencing defects conferred by missense mutations within the Rap1p C-terminal tail domain (aa 800-827). Each SIR3 suppressor was also capable of suppressing a rap1 allele (rap1-21), which deletes the 28 aa C-terminal tail domain, but none of the suppressors restored telometric silencing to a 165 amino acid truncation allele. These data suggest a Rap1p...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Alleles
Share to Binding Sites
Share to Fungal Proteins

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Genes, Fungal

Share to Genotype

Share to Restriction Mapping

Share to Saccharomyces cerevisiae

Share to Transcription, Genetic

Source

Open in PubMed Open full text

Identifiers

PMID: 8722764
DOI: 10.1093/genetics/143.1.81
PMCID: PMC1207297

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Genetic analysis of Rap1p/Sir3p interactions in telomeric and HML silencing in Saccharomyces cerevisiae.PMID 8722764Read ↗

Mutational analysis defines a C-terminal tail domain of RAP1 essential for Telomeric silencing in Saccharomyces cerevisiae.Semantic proximity Read ↗

C-terminal truncation of RAP1 results in the deregulation of telomere size, stability, and function in Saccharomyces cerevisiae.Semantic proximity Read ↗

A novel Rap1p-interacting factor, Rif2p, cooperates with Rif1p to regulate telomere length in Saccharomyces cerevisiae.Semantic proximity Read ↗

Structural and functional studies of the Rap1 C-terminus reveal novel separation-of-function mutants.Semantic proximity Read ↗

Evidence that a complex of SIR proteins interacts with the silencer and telomere-binding protein RAP1.Semantic proximity Read ↗

Spreading of transcriptional repressor SIR3 from telomeric heterochromatin.Semantic proximity Read ↗

Tethered Sir3p nucleates silencing at telomeres and internal loci in Saccharomyces cerevisiae.Semantic proximity Read ↗

A RAP1-interacting protein involved in transcriptional silencing and telomere length regulation.Semantic proximity Read ↗

Separation of transcriptional activation and silencing functions of the RAP1-encoded repressor/activator protein 1: isolation of viable mutants affecting both silencing and telomere length.Semantic proximity Read ↗

Involvement of the silencer and UAS binding protein RAP1 in regulation of telomere length.Semantic proximity Read ↗

Identification of a novel allele of SIR3 defective in the maintenance, but not the establishment, of silencing in Saccharomyces cerevisiae.Semantic proximity Read ↗

SIR3 and SIR4 proteins are required for the positioning and integrity of yeast telomeres.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.