Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

C-terminal truncation of RAP1 results in the deregulation of telomere size, stability, and function in Saccharomyces cerevisiae.

Molecular and cellular biology - 1 Nov 1992

Kyrion G, Boakye K A, Lustig A J

Abstract excerpt

The Saccharomyces cerevisiae DNA-binding protein RAP1 is capable of binding in vitro to sequences from a wide variety of genomic loci, including upstream activating sequence elements, the HML and HMR silencer regions, and the poly(G1-3T) tracts of telomeres. Recent biochemical and genetic studies have suggested that RAP1 physically and functionally interacts with the yeast telomere. To further investigate the...

Topics

Alleles
Amino Acid Sequence
Base Sequence
Chromosome Deletion
DNA, Fungal
GTP-Binding Proteins
Molecular Sequence Data
Mutation
Nondisjunction, Genetic
Saccharomyces cerevisiae
Telomere

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

rap GTP-Binding Proteins

Source

Open in PubMed Open full text

Identifiers

PMID: 1406688
DOI: 10.1128/mcb.12.11.5159-5173.1992
PMCID: PMC360450

Genes

RAD1
RAD52

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-1406688-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

0

discussions

0

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

C-terminal truncation of RAP1 results in the deregulation of telomere size, stability, and function in Saccharomyces cerevisiae.PMID 1406688Read ↗

Mutational analysis defines a C-terminal tail domain of RAP1 essential for Telomeric silencing in Saccharomyces cerevisiae.Semantic proximity Read ↗

A RAP1-interacting protein involved in transcriptional silencing and telomere length regulation.Semantic proximity Read ↗

Structural and functional studies of the Rap1 C-terminus reveal novel separation-of-function mutants.Semantic proximity Read ↗

A novel Rap1p-interacting factor, Rif2p, cooperates with Rif1p to regulate telomere length in Saccharomyces cerevisiae.Semantic proximity Read ↗

Rap1 in Candida albicans: an unusual structural organization and a critical function in suppressing telomere recombination.Semantic proximity Read ↗

Genetic analysis of Rap1p/Sir3p interactions in telomeric and HML silencing in Saccharomyces cerevisiae.Semantic proximity Read ↗

Involvement of the silencer and UAS binding protein RAP1 in regulation of telomere length.Semantic proximity Read ↗

Yeast Rap1 contributes to genomic integrity by activating DNA damage repair genes.Semantic proximity Read ↗

Rap1 protein regulates telomere turnover in yeast.Semantic proximity Read ↗

Intrachromatid excision of telomeric DNA as a mechanism for telomere size control in Saccharomyces cerevisiae.Semantic proximity Read ↗

Separation of transcriptional activation and silencing functions of the RAP1-encoded repressor/activator protein 1: isolation of viable mutants affecting both silencing and telomere length.Semantic proximity Read ↗

Aberrant expression and localization of the RAP1 shelterin protein contribute to age-related phenotypes.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.