Article
The transcriptional activity of a muscle-specific promoter depends critically on the structure of the TATA element and its binding protein.
Journal of molecular biology - 7 Feb 1997
Diagana T T, North D L, Jabet C, Fiszman M Y, Takeda S, Whalen R G
Abstract excerpt
We have previously characterized the proximal promoter of the mouse IIB myosin heavy chain (MyHC) gene, which is expressed only in fast-contracting glycolytic skeletal muscle fibers. We show here that the substitution into this promoter of a non-canonical TATA sequence from the IgH gene results i...
Topics
- Amino Acid Sequence
- Animals
- Conserved Sequence
- DNA
- DNA Footprinting
- DNA-Binding Proteins
- Evolution, Molecular
- Humans
- Immunoglobulin Heavy Chains
- Mice
- Molecular Structure
- Muscle, Skeletal
- Mutation
- Myosin Heavy Chains
- Nucleic Acid Conformation
- Promoter Regions, Genetic
- Protein Binding
- Protein Conformation