Article
Synergistic interactions between heterologous upstream activation elements and specific TATA sequences in a muscle-specific promoter.
Molecular and cellular biology - 1 Apr 1995
Grayson J, Williams R S, Yu Y T, Bassel-Duby R
Abstract excerpt
Previous investigations have defined three upstream activation elements--CCAC, A/T, and TATA sequences--necessary for muscle-specific transcription of the myoglobin gene. In the present study, we demonstrate that these three sequences elements, prepared as synthetic oligonucleotide cassettes, fun...
Topics
- Animals
- Base Sequence
- Binding Sites
- Consensus Sequence
- DNA-Binding Proteins
- Gene Expression Regulation
- MEF2 Transcription Factors
- Mice
- Molecular Sequence Data
- Muscle Development
- Muscles
- Mutation
- Myogenic Regulatory Factors
- Myoglobin
- Protein Binding
- TATA Box
- Tissue Distribution
- Transcription Factors