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Article

Synergistic interactions between heterologous upstream activation elements and specific TATA sequences in a muscle-specific promoter.

Molecular and cellular biology - 1 Apr 1995

Grayson J, Williams R S, Yu Y T, Bassel-Duby R

Abstract excerpt

Previous investigations have defined three upstream activation elements--CCAC, A/T, and TATA sequences--necessary for muscle-specific transcription of the myoglobin gene. In the present study, we demonstrate that these three sequences elements, prepared as synthetic oligonucleotide cassettes, function synergistically to constitute a cell-type-specific transcription unit. Previously, cognate binding factors that...

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Identifiers

PMID: 7891680
DOI: 10.1128/MCB.15.4.1870
PMCID: PMC230412

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Source receipt: pubmed, retrieved 7 Sept 2026.

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