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Article

An E-box within the MHC IIB gene is bound by MyoD and is required for gene expression in fast muscle

1 May 1999

Abstract excerpt

The myosin heavy chain (MHC) IIB gene is selectively expressed in skeletal muscles, imparting fast contractile kinetics. Why the MHC IIB gene product is expressed in muscles like the tibialis anterior (TA) and not expressed in muscles like the soleus is currently unclear. It is shown here that the mutation of an E-box within the MHC IIB promoter decreased reporter gene activity in the fast-twitch TA muscle...

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Identifiers

PMID: 10329954
DOI: 10.1152/ajpcell.1999.276.5.c1069

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An E-box within the MHC IIB gene is bound by MyoD and is required for gene expression in fast musclePMID 10329954Read ↗

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