Article
A 40-kilodalton protein binds specifically to an upstream sequence element essential for muscle-specific transcription of the human myoglobin promoter.
Molecular and cellular biology - 1 Nov 1992
Bassel-Duby R, Hernandez M D, Gonzalez M A, Krueger J K, Williams R S
Abstract excerpt
To define transcriptional control elements responsible for muscle-specific expression of the human myoglobin gene, we performed mutational analysis of upstream sequences (nucleotide positions -373 to +7 relative to the transcriptional start site) linked to a firefly luciferase gene. Transient exp...
Topics
- Animals
- Base Sequence
- Cell Line
- DNA
- DNA-Binding Proteins
- Humans
- Luciferases
- Mice
- Molecular Sequence Data
- Muscles
- Mutation
- Myoglobin
- Organ Specificity
- Promoter Regions, Genetic
- Protein Binding
- Regulatory Sequences, Nucleic Acid