Article
Functional heterogeneity of mammalian TATA-box sequences revealed by interaction with a cell-specific enhancer.
Nature - 15 Mar 1990
Wefald F C, Devlin B H, Williams R S
Abstract excerpt
A regulatory element upstream of the human myoglobin gene functions as a muscle-specific enhancer (MSE) in conjunction with core promoter elements of the myoglobin gene, but not in combination with the simian virus 40 (SV40) early promoter. These two promoters differ in the sequences of their 'TATA boxes': for the myoglobin gene, the sequence is TATAAAA, whereas for SV40, the sequence is TATTTAT. We have now...
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