Functional heterogeneity of mammalian TATA-box sequences revealed by interaction with a cell-specific enhancer.

doi:10.1038/344260a0

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Article

Functional heterogeneity of mammalian TATA-box sequences revealed by interaction with a cell-specific enhancer.

Nature - 15 Mar 1990

Wefald F C, Devlin B H, Williams R S

Abstract excerpt

A regulatory element upstream of the human myoglobin gene functions as a muscle-specific enhancer (MSE) in conjunction with core promoter elements of the myoglobin gene, but not in combination with the simian virus 40 (SV40) early promoter. These two promoters differ in the sequences of their 'TA...

Topics

Chloramphenicol O-Acetyltransferase
Cloning, Molecular
Creatine Kinase
DNA
Enhancer Elements, Genetic
Gene Expression
Humans
Isoenzymes
Mutation
Myoglobin
Promoter Regions, Genetic
Regulatory Sequences, Nucleic Acid
Simian virus 40
Transcription, Genetic

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