Article
Mechanism of tissue-specific transcription: interplay between positive and negative regulatory factors.
Gene expression - 1 Jan 1992
Zhou M D, Wu Y, Kumar A, Siddiqui M A
Abstract excerpt
At least four regulatory cis-acting DNA sequences, CCAAAAGTGG (element A), TTATTTTTA (element B), TATTTATT (element C), and TATTACCTTTAT (element S), were identified in cardiac myosin light chain-2 (MLC2) proximal promoter as target sites for sequence-specific binding of nuclear proteins. For muscle-specific transcription, the proximal promoter (-53 to +1) consisting only of elements B and C is required. Addition...
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