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IIb or not IIb? Regulation of myosin heavy chain gene expression in mice and men

1 Feb 2011

Abstract excerpt

BACKGROUND: While the myosin heavy chain IIb isoform (MyHC-IIb) is the predominant motor protein in most skeletal muscles of rats and mice, the messenger RNA (mRNA) for this isoform is only expressed in a very small subset of specialized muscles in adult large mammals, including humans. RESULTS: We identify the DNA sequences limiting MyHC-IIb expression in humans and explore the activation of this gene in human...

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PMID: 21798083
DOI: 10.1186/2044-5040-1-5

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