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Article

The xid mutation plays an important role in delayed development of murine acquired immunodeficiency syndrome.

International immunology - 1 Jan 1997

Numata F, Hitoshi Y, Uehara S, Takatsu K

Abstract excerpt

Infection of C57BL/6 mice with LP-BM5 murine leukemia virus (MuLV) leads to the development of murine acquired immunodeficiency syndrome (MAIDS) characterized by abnormal lymphoproliferation, hypergammaglobulinemia and severe immunodeficiency. Progression of MAIDS is delayed in X chromosome-linked immunodeficient (XID) mice, which have an abnormality of Bruton's tyrosine kinase (Btk) and lack functionally mature...

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Source

Identifiers

PMID: 9043955
DOI: 10.1093/intimm/9.1.139

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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The xid mutation plays an important role in delayed development of murine acquired immunodeficiency syndrome.PMID 9043955Read ↗

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Accelerated progression of a murine retrovirus-induced immunodeficiency syndrome in Fas mutant C57BL/6 lpr/lpr mice.Semantic proximity Read ↗

Depletion of peritoneal CD5+ B cells has no effect on the course of Leishmania major infection in susceptible and resistant mice.Semantic proximity Read ↗

Transgene expression of bcl-xL permits anti-immunoglobulin (Ig)-induced proliferation in xid B cells.Semantic proximity Read ↗

Functional and phenotypic change of T cells in murine acquired immune deficiency.Semantic proximity Read ↗

A re-evaluation of the effects of X-linked immunodeficiency (xid) mutation on B cell differentiation and function in the mouse.Semantic proximity Read ↗

The Xid defect determines an improved clinical course of murine leishmaniasis in susceptible miceSemantic proximity Read ↗

Mouse germinal center B cells with the xid mutation retain responsiveness to antimouse CD40 antibodies but diminish IL-5 responsiveness.Semantic proximity Read ↗

Mutation of Unique Region of Bruton's Tyrosine Kinase in Immunodeficient XID MiceSemantic proximity Read ↗

The autoimmune accelerating yaa mutation does not accelerate murine AIDS.Semantic proximity Read ↗

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