Article
The xid mutation plays an important role in delayed development of murine acquired immunodeficiency syndrome.
International immunology - 1 Jan 1997
Numata F, Hitoshi Y, Uehara S, Takatsu K
Abstract excerpt
Infection of C57BL/6 mice with LP-BM5 murine leukemia virus (MuLV) leads to the development of murine acquired immunodeficiency syndrome (MAIDS) characterized by abnormal lymphoproliferation, hypergammaglobulinemia and severe immunodeficiency. Progression of MAIDS is delayed in X chromosome-linke...
Topics
- Adoptive Transfer
- Agammaglobulinaemia Tyrosine Kinase
- Animals
- B-Lymphocytes
- Disease Susceptibility
- Female
- Hypergammaglobulinemia
- Leukemia Virus, Murine
- Lymphocyte Activation
- Mice
- Mice, Inbred C57BL
- Murine Acquired Immunodeficiency Syndrome
- Mutation
- Protein-Tyrosine Kinases
- Retroviridae Infections
- Severe Combined Immunodeficiency
- Tumor Virus Infections
- X Chromosome