Article
Mouse germinal center B cells with the xid mutation retain responsiveness to antimouse CD40 antibodies but diminish IL-5 responsiveness.
International immunology - 1 Oct 1997
Baba M, Kikuchi Y, Mori S, Kimoto H, Inui S, Sakaguchi N, Inoue J, Yamamoto T, Takemori T, Howard M, Takatsu K
Abstract excerpt
The germinal center (GC) develops in secondary lymphoid tissues in response to thymus-dependent (TD) antigens. To investigate the molecular mechanism of B cell differentiation in GC, we enriched GC B cells from spleen of TD antigen-immunized wild-type and X-linked immunodeficient (XID) mice, and examined the differentiation of GC B cells into antigen-specific IgG1 antibody-forming cells (AFC) in response to...
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