Depletion of peritoneal CD5+ B cells has no effect on the course of Leishmania major infection in susceptible and resistant mice.

doi:10.1046/j.1365-2249.1999.00953.x

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Article

Depletion of peritoneal CD5+ B cells has no effect on the course of Leishmania major infection in susceptible and resistant mice.

Clinical and experimental immunology - 1 Jul 1999

Babai B, Louzir H, Cazenave P A, Dellagi K

Abstract excerpt

The mouse peritoneal cavity contains a unique self-renewing population of B cells (B-1) derived from fetal liver precursors and mainly producing polyreactive antibodies. Since B-1 cells are a potential source of IL-10, it has been suggested that these cells may contribute to the susceptibility of BALB/c mice to Leishmania major infection by skewing the T helper cell network towards a Th2 phenotype. Accordingly,...

Topics

Actins
Animals
Autoantibodies
B-Lymphocyte Subsets
CD5 Antigens
Disease Progression
Female
Genetic Predisposition to Disease
Immunoglobulin G
Immunologic Deficiency Syndromes
Interleukin-10
Leishmania major
Leishmaniasis, Cutaneous

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Lymphocyte Count

Mice

Mice, Inbred BALB C

Mice, Inbred C57BL

Mice, Mutant Strains

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Identifiers

PMID: 10403925
DOI: 10.1046/j.1365-2249.1999.00953.x
PMCID: PMC1905474

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