Article
Xid-like immunodeficiency in mice with disruption of the p85alpha subunit of phosphoinositide 3-kinase.
Science (New York, N.Y.) - 15 Jan 1999
Suzuki H, Terauchi Y, Fujiwara M, Aizawa S, Yazaki Y, Kadowaki T, Koyasu S
Abstract excerpt
Mice with a targeted gene disruption of p85alpha, a regulatory subunit of phosphoinositide 3-kinase, had impaired B cell development at the pro-B cell stage, reduced numbers of mature B cells and peritoneal CD5+ Ly-1 B cells, reduced B cell proliferative responses, and no T cell-independent antib...
Topics
- Agammaglobulinaemia Tyrosine Kinase
- Animals
- Antibody Formation
- Antigens, Ly
- Antigens, T-Independent
- B-Lymphocyte Subsets
- B-Lymphocytes
- Bone Marrow
- CD5 Antigens
- Cell Survival
- Gene Targeting
- Genetic Linkage
- Immunologic Deficiency Syndromes
- Lymphocyte Count
- Lymphoid Tissue
- Mice
- Mutation
- Phenotype