Article
Transgene expression of bcl-xL permits anti-immunoglobulin (Ig)-induced proliferation in xid B cells.
The Journal of experimental medicine - 6 Apr 1998
Solvason N, Wu W W, Kabra N, Lund-Johansen F, Roncarolo M G, Behrens T W, Grillot D A, Nunez G, Lees E, Howard M
Abstract excerpt
Mutations in the tyrosine kinase, Btk, result in a mild immunodeficiency in mice (xid). While B lymphocytes from xid mice do not proliferate to anti-immunoglobulin (Ig), we show here induction of the complete complement of cell cycle regulatory molecules, though the level of induction is about half that detected in normal B cells. Cell cycle analysis reveals that anti-Ig stimulated xid B cells enter S phase, but...
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