Article
A re-evaluation of the effects of X-linked immunodeficiency (xid) mutation on B cell differentiation and function in the mouse.
European journal of immunology - 1 Nov 1997
Klaus G G, Holman M, Johnson-Léger C, Elgueta-Karstegl C, Atkins C
Abstract excerpt
CBA/N (xid) mice have a point mutation in Bruton's tyrosine kinase (btk), which results in their failure to respond to T-independent type 2 (TI-2) antigens, and to several B cell mitogens [most notably anti-immunoglobulin (Ig)] in vitro. They have reduced numbers of peripheral (B2) B cells, which...
Topics
- Animals
- B-Lymphocyte Subsets
- Cell Differentiation
- Female
- Genetic Linkage
- Immunologic Deficiency Syndromes
- Immunophenotyping
- Lymphocyte Activation
- Male
- Mice
- Mice, Inbred C57BL
- Mice, Inbred CBA
- Mice, Mutant Strains
- Mitogens
- Mutation
- Proto-Oncogene Proteins c-bcl-2
- X Chromosome