Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

A re-evaluation of the effects of X-linked immunodeficiency (xid) mutation on B cell differentiation and function in the mouse.

European journal of immunology - 1 Nov 1997

Klaus G G, Holman M, Johnson-Léger C, Elgueta-Karstegl C, Atkins C

Abstract excerpt

CBA/N (xid) mice have a point mutation in Bruton's tyrosine kinase (btk), which results in their failure to respond to T-independent type 2 (TI-2) antigens, and to several B cell mitogens [most notably anti-immunoglobulin (Ig)] in vitro. They have reduced numbers of peripheral (B2) B cells, which are regarded as being phenotypically and functionally immature. We show here that adult CBA/N mice in fact have two...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cell Differentiation
Share to Genetic Linkage

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Lymphocyte Activation

Share to Mice, Inbred C57BL

Share to Mice, Mutant Strains

Share to Mutation

Share to X Chromosome

Source

Identifiers

PMID: 9394795
DOI: 10.1002/eji.1830271102

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

A re-evaluation of the effects of X-linked immunodeficiency (xid) mutation on B cell differentiation and function in the mouse.PMID 9394795Read ↗

Tracking the response of Xid B cells in vivo: TI-2 antigen induces migration and proliferation but Btk is essential for terminal differentiation.Semantic proximity Read ↗

Interleukin-10 production by lung macrophages in CBA xid mutant mice infected with Mycobacterium tuberculosis.Semantic proximity Read ↗

xid affects events leading to B cell cycle entry.Semantic proximity Read ↗

Role of Bruton's tyrosine kinase in B cell development.Semantic proximity Read ↗

Resolution of three nonproliferative immature splenic B cell subsets reveals multiple selection points during peripheral B cell maturation.Semantic proximity Read ↗

Defective B cell development and function in Btk-deficient mice.Semantic proximity Read ↗

bcl-2 alters the antigen-driven selection of B cells in mukappa but not in mu-only Xid transgenic mice.Semantic proximity Read ↗

Inactivation of Btk by insertion of lacZ reveals defects in B cell development only past the pre-B cell stage.Semantic proximity Read ↗

Transgene expression of bcl-xL permits anti-immunoglobulin (Ig)-induced proliferation in xid B cells.Semantic proximity Read ↗

Composition of precursor B-cell compartment in bone marrow from patients with X-linked agammaglobulinemia compared with healthy children.Semantic proximity Read ↗

Importance of B cell co-stimulation in CD4(+) T cell differentiation: X-linked agammaglobulinaemia, a human model.Semantic proximity Read ↗

B-1a transitional cells are phenotypically distinct and are lacking in mice deficient in IκBNS.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.