Article
Contribution of B cell subsets to delayed development of MAIDS in xid mice.
Cellular immunology - 1 Oct 1995
Tang Y, Kim W K, Holmes K L, Hügin A W, Kenny J J, Chattopadhyay S K, Hartley J W, Morse H C
Abstract excerpt
C57BL/6 (B6) mice develop a syndrome of progressive lymphoproliferation and immunodeficiency, murine AIDS (MAIDS), when infected with an etiologic replication-defective virus termed BM5def. Induction of MAIDS requires the presence of CD4+ T cells and B cells. B6 mice with altered conventional B cell function and a deficit in CD5+ B cells due to the xid mutation develop disease with a greatly prolonged latency....
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