Article
Genetic changes of both p53 alleles associated with the conversion from colorectal adenoma to early carcinoma in familial adenomatous polyposis and non-familial adenomatous polyposis patients.
Cancer research - 15 Jul 1992
Kikuchi-Yanoshita R, Konishi M, Ito S, Seki M, Tanaka K, Maeda Y, Iino H, Fukayama M, Koike M, Mori T
Abstract excerpt
Mutation and loss of heterozygosity (LOH) in the p53 gene were analyzed in 274 colorectal tumors of 4 histopathological grades. Among 160 tumors from 40 familial adenomatous polyposis patients, none of 58 adenomas with moderate dysplasia had p53 mutations, whereas 8% (3 of 37) of severe adenomas, 15% (6 of 40) of intramucosal carcinomas, and 40% (10 of 25) of invasive carcinomas had p53 mutations. Only 3% (1 of...
Topics
- Adenoma
- Adenomatous Polyposis Coli
- Alleles
- Amino Acid Sequence
- Carcinoma
- Chromosome Deletion
- Chromosomes, Human, Pair 17
- Colorectal Neoplasms
- Genes, p53
- Heterozygote