[Analysis of genetic changes in progression of colorectal cancer].

Article

[Analysis of genetic changes in progression of colorectal cancer].

Gan to kagaku ryoho. Cancer & chemotherapy - 1 Jun 1996

Kuroda K, Watatani M, Yoshida T, Ieda S, Shindo K, Yasutomi M

Abstract excerpt

To investigate whether genetic changes of the p53 gene and genetic defects in DNA-mismatch repair systems are involved in progression of colorectal carcinomas (CRCs), we examined loss of heterozygosity (LOH) on 17p and mutations in exon 5 through 8 of the p53 gene as well as replication errors (R...

Topics

Chromosomes, Human, Pair 17
Colorectal Neoplasms
DNA, Neoplasm
Genes, p53
Heterozygote
Humans
Microsatellite Repeats
Mutation

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

discussions

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.