Article
Loss of heterozygosity testing using real-time PCR analysis of single nucleotide polymorphisms.
Journal of cancer research and clinical oncology - 1 Mar 2006
Cacev Tamara, Jokić Mladen, Spaventi Radan, Pavelić Kresimir, Kapitanović Sanja
Abstract excerpt
PURPOSE: Colon cancer is a genetic disease, caused by mutations in different oncogenes and tumor-suppressor genes. The aim of this study is to evaluate the usefulness of real-time PCR SNP analysis as a new technique in the loss of heterozygosity (LOH) analysis at the E-cadherin gene locus in sporadic colon cancer. METHODS: One-hundred cases of human sporadic colon cancer and corresponding normal tissue samples...
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