Article
A frequent alteration of p53 gene in carcinoma in adenoma of colon.
Cancer research - 1 Sept 1994
Ohue M, Tomita N, Monden T, Fujita M, Fukunaga M, Takami K, Yana I, Ohnishi T, Enomoto T, Inoue M
Abstract excerpt
In general, colorectal carcinoma is thought to originate mainly from adenoma, and this pathway is called the adenoma-carcinoma sequence. Carcinoma in adenoma is an appropriate model for analysis of this mechanism, because adenoma and carcinoma tissues coexist in the same polyp and the carcinoma is thought to have originated from the surrounding adenoma. Expression of the p53 protein was analyzed in 36 cases of...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.
