A frequent alteration of p53 gene in carcinoma in adenoma of colon.

Article

A frequent alteration of p53 gene in carcinoma in adenoma of colon.

Cancer research - 1 Sept 1994

Ohue M, Tomita N, Monden T, Fujita M, Fukunaga M, Takami K, Yana I, Ohnishi T, Enomoto T, Inoue M

Abstract excerpt

In general, colorectal carcinoma is thought to originate mainly from adenoma, and this pathway is called the adenoma-carcinoma sequence. Carcinoma in adenoma is an appropriate model for analysis of this mechanism, because adenoma and carcinoma tissues coexist in the same polyp and the carcinoma i...

Topics

Adenocarcinoma
Adenoma
Base Sequence
Colonic Neoplasms
Exons
Gene Deletion
Genes, p53
Humans
Molecular Sequence Data
Mutation
Polymerase Chain Reaction
Tumor Suppressor Protein p53

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