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Article

Mutation analysis of p53, K-ras, and BRAF genes in colorectal cancer progression.

Journal of cellular physiology - 1 Aug 2005

Calistri Daniele, Rengucci Claudia, Seymour Ian, Lattuneddu Arturo, Polifemo Anna Maria, Monti Franco, Saragoni Luca, Amadori Dino

Abstract excerpt

Gene mutations in APC, K-ras, and p53 are thought to be essential events for colorectal cancer development. Recent data seem to indicate that K-ras and p53 mutations rarely co-exist in the same tumor, indicating that these alterations do not represent a synergistic evolutionary pathway. Moreover, an inverse relation between K-ras gene activation and BRAF mutations has been demonstrated, suggesting alternative...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to DNA Mutational Analysis

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Share to Polymorphism, Single-Stranded Conformational

Share to Proto-Oncogene Proteins B-raf

Source

Identifiers

PMID: 15702478
DOI: 10.1002/jcp.20310

Genes

BRAF
APC

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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