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Article

No major difference in K-ras and p53 abnormalities in sporadic and hereditary nonpolyposis colorectal adenomas.

Digestive diseases and sciences - 1 Nov 2000

Voskuil D W, Kampman E, van Geloof W, Grubben M, Kok F, van Muijen G, Nagengast F, Vasen H, van't Veer P

Abstract excerpt

K-ras and p53 gene mutations are known to occur in high frequencies in sporadic colorectal cancers, but findings are inconsistent in hereditary nonpolyposis colorectal cancer (HNPCC). We compared K-ras codon 12 and 13 gene mutations and p53 protein overexpression in 48 HNPCC (positive for Amsterdam criteria) and 59 sporadic colorectal adenomas, to examine whether they may represent similar or different molecular...

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Identifiers

PMID: 11215737
DOI: 10.1023/a:1026485117125

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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