Article
Tumorigenesis in colorectal tumors from patients with hereditary non-polyposis colorectal cancer.
Human genetics - 1 Nov 1997
Tannergård P, Liu T, Weger A, Nordenskjöld M, Lindblom A
Abstract excerpt
Tumorigenesis of colorectal cancer in patients with hereditary non-polyposis colorectal cancer (HNPCC) has been postulated to follow a different pathway from that of sporadic colorectal tumors. A characteristic of HNPCC-associated tumors is the replication error phenotype. We studied tumorigenesi...
Topics
- Alleles
- Base Sequence
- Colorectal Neoplasms, Hereditary Nonpolyposis
- DNA Primers
- DNA Replication
- Frameshift Mutation
- Genes, ras
- Genetic Markers
- Humans
- Loss of Heterozygosity
- Microsatellite Repeats
- Mutation
- Phenotype
- Polymerase Chain Reaction
- Protein Serine-Threonine Kinases
- Receptor, Transforming Growth Factor-beta Type II
- Receptors, Transforming Growth Factor beta