Article
Tumorigenesis in colorectal tumors from patients with hereditary non-polyposis colorectal cancer.
Human genetics - 1 Nov 1997
Tannergård P, Liu T, Weger A, Nordenskjöld M, Lindblom A
Abstract excerpt
Tumorigenesis of colorectal cancer in patients with hereditary non-polyposis colorectal cancer (HNPCC) has been postulated to follow a different pathway from that of sporadic colorectal tumors. A characteristic of HNPCC-associated tumors is the replication error phenotype. We studied tumorigenesis in 8 fresh-frozen and 67 paraffin-embedded colorectal tumors derived from 29 families with HNPCC or a familial...
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