Molecular nature of colon tumors in hereditary nonpolyposis colon cancer, familial polyposis, and sporadic colon cancer.

doi:10.1053/gast.1996.v111.pm8690195

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Article

Molecular nature of colon tumors in hereditary nonpolyposis colon cancer, familial polyposis, and sporadic colon cancer.

Gastroenterology - 1 Aug 1996

Konishi M, Kikuchi-Yanoshita R, Tanaka K, Muraoka M, Onda A, Okumura Y, Kishi N, Iwama T, Mori T, Koike M, Ushio K, Chiba M, Nomizu S, Konishi F, Utsunomiya J, Miyaki M

Abstract excerpt

BACKGROUND & AIMS: Microsatellite instability (replication error [RER]) is a characteristic of tumors in hereditary nonpolyposis colon cancer (HNPCC), but the mechanism of HNPCC carcinogenesis is not yet understood. To clarify the nature of HNPCC tumors, RER and genetic changes were compared between HNPCC and non-HNPCC tumors. METHODS: RER and genetic changes were analyzed in 21 HNPCC, 389 familial adenomatous...

Topics

Adaptor Proteins, Signal Transducing
Adenoma
Adenomatous Polyposis Coli
Adult
Base Sequence
Blotting, Southern
Carcinoma
Colonic Neoplasms
Colorectal Neoplasms, Hereditary Nonpolyposis
DNA Replication

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

DNA-Binding Proteins

Fungal Proteins

Genes, APC

Genes, p53

Genes, ras

Humans

Microsatellite Repeats

Middle Aged

Source

Open in PubMed

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PMID: 8690195
DOI: 10.1053/gast.1996.v111.pm8690195

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