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Article

Somatic mutations of the APC, KRAS, and TP53 genes in nonpolypoid colorectal adenomas.

Genes, chromosomes & cancer - 1 Feb 2000

van Wyk R, Slezak P, Hayes V M, Buys C H, Kotze M J, de Jong G, Rubio C, Dolk A, Jaramillo E, Koizumi K, Grobbelaar J J

Abstract excerpt

Colorectal adenomas are macroscopically visible morphological changes of the mucosa that can develop focal carcinoma in the absence of surgical intervention. The successive molecular changes proposed to occur at different stages in the adenoma-carcinoma sequence were primarily based on DNA studies of exophytic, polypoid-type adenomas. Not all colorectal lesions, however, display an exophytic phenotype and a...

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PMID: 10612810

Genes

KRAS
APC

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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