Somatic mutations of the APC, KRAS, and TP53 genes in nonpolypoid colorectal adenomas.

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Article

Somatic mutations of the APC, KRAS, and TP53 genes in nonpolypoid colorectal adenomas.

Genes, chromosomes & cancer - 1 Feb 2000

van Wyk R, Slezak P, Hayes V M, Buys C H, Kotze M J, de Jong G, Rubio C, Dolk A, Jaramillo E, Koizumi K, Grobbelaar J J

Abstract excerpt

Colorectal adenomas are macroscopically visible morphological changes of the mucosa that can develop focal carcinoma in the absence of surgical intervention. The successive molecular changes proposed to occur at different stages in the adenoma-carcinoma sequence were primarily based on DNA studies of exophytic, polypoid-type adenomas. Not all colorectal lesions, however, display an exophytic phenotype and a...

Topics

Adenoma
Aged
Aged, 80 and over
Amino Acid Substitution
Base Sequence
Colorectal Neoplasms
DNA
DNA Mutational Analysis
Frameshift Mutation
Genes
Genes, APC
Genes, p53
Genes, ras
Humans

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Middle Aged

Mutation

Mutation, Missense

Point Mutation

Source

Open in PubMed

Identifiers

PMID: 10612810

Genes

KRAS
APC

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026.