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Article

Simultaneous mutations in K-ras and TP53 are indicative of poor prognosis in sporadic colorectal cancer.

American journal of clinical oncology - 1 Feb 2004

González-Aguilera Juan J, Oliart Soledad, Azcoita Mariano Moreno, Fernández-Peralta Antonia M

Abstract excerpt

Despite the fact that the mutations in K-ras codon 12 and TP53 are common abnormalities in colorectal cancer, the determination of K-ras mutation combined with TP53 gene mutation, with diagnostic and prognostic purposes is still controversial. We have analyzed K-ras and TP53 mutations in 77 sporadic colorectal adenocarcinomas by means of polymerase chain reaction and sequencing. We observed a negative correlation...

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Identifiers

PMID: 14758132
DOI: 10.1097/01.coc.0000045920.49210.7a

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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