p53 and K-ras gene mutations in carcinoma of the rectum among Finnish women.

doi:10.1136/mp.53.1.24

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Article

p53 and K-ras gene mutations in carcinoma of the rectum among Finnish women.

Molecular pathology : MP - 1 Feb 2000

Servomaa K, Kiuru A, Kosma V M, Hirvikoski P, Rytömaa T

Abstract excerpt

AIMS/BACKGROUND: The aim of this study was to identify p53 and K-ras gene mutations in carcinoma of the rectum among Finnish women. Mutation patterns might give clues to aetiological factors when comparisons are made with other human tumours. METHODS: Of 134 women with carcinoma of the rectum, paraffin wax embedded specimens of the tumour tissue were obtained from 118 patients. Genomic DNA was extracted, and...

Topics

Age Factors
Aged
Female
Genes, p53
Genes, ras
Humans
Middle Aged
Mutation
Paraffin Embedding
Polymorphism, Single-Stranded Conformational
Rectal Neoplasms
Sequence Analysis, DNA

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Identifiers

PMID: 10884918
DOI: 10.1136/mp.53.1.24
PMCID: PMC1186898

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