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Article

Inverse relationship between microsatellite instability and K-ras and p53 gene alterations in colon cancer.

The American journal of pathology - 1 Apr 2001

Samowitz W S, Holden J A, Curtin K, Edwards S L, Walker A R, Lin H A, Robertson M A, Nichols M F, Gruenthal K M, Lynch B J, Leppert M F, Slattery M L

Abstract excerpt

Some studies have shown an inverse relationship between microsatellite instability in colon cancer and mutations in p53 and K-ras, whereas others have not. We therefore evaluated these features in a population-based sample of 496 individuals with colon cancer. Microsatellite instability was determined by a panel of 10 tetranucleotide repeats, the Bethesda consensus panel of mono- and dinucleotide repeats, and...

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Identifiers

PMID: 11290569
DOI: 10.1016/S0002-9440(10)64102-8
PMCID: PMC1891913

Genes

BAX

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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