Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

The G2/M DNA damage checkpoint inhibits mitosis through Tyr15 phosphorylation of p34cdc2 in Aspergillus nidulans.

The EMBO journal - 2 Jan 1997

Ye X S, Fincher R R, Tang A, Osmani S A

Abstract excerpt

It is possible to cause G2 arrest in Aspergillus nidulans by inactivating either p34cdc2 or NIMA. We therefore investigated the negative control of these two mitosis-promoting kinases after DNA damage. DNA damage caused rapid Tyr15 phosphorylation of p34cdc2 and transient cell cycle arrest but had little effect on the activity of NIMA. Dividing cells deficient in Tyr15 phosphorylation of p34cdc2 were sensitive to...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cell Cycle Proteins
Share to DNA Damage
Share to DNA, Fungal

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to DNA Repair

Share to Mutation

Share to Phosphorylation

Share to Protein Serine-Threonine Kinases

Share to Ultraviolet Rays

Source

Open in PubMed Open full text

Identifiers

PMID: 9009279
DOI: 10.1093/emboj/16.1.182
PMCID: PMC1169625

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

The G2/M DNA damage checkpoint inhibits mitosis through Tyr15 phosphorylation of p34cdc2 in Aspergillus nidulans.PMID 9009279Read ↗

Two S-phase checkpoint systems, one involving the function of both BIME and Tyr15 phosphorylation of p34cdc2, inhibit NIMA and prevent premature mitosis.Semantic proximity Read ↗

Parallel activation of the NIMA and p34cdc2 cell cycle-regulated protein kinases is required to initiate mitosis in A. nidulans.Semantic proximity Read ↗

The Aspergillus nidulans snt genes are required for the regulation of septum formation and cell cycle checkpoints.Semantic proximity Read ↗

Checkpoint defects leading to premature mitosis also cause endoreplication of DNA in Aspergillus nidulans.Semantic proximity Read ↗

The NIMA protein kinase is hyperphosphorylated and activated downstream of p34cdc2/cyclin B: coordination of two mitosis promoting kinases.Semantic proximity Read ↗

Cdc2 tyrosine phosphorylation is not required for the S-phase DNA damage checkpoint in fission yeast.Semantic proximity Read ↗

Essential roles for calcium and calmodulin in G2/M progression in Aspergillus nidulans.Semantic proximity Read ↗

A single p34cdc2 protein kinase (encoded by nimXcdc2) is required at G1 and G2 in Aspergillus nidulans.Semantic proximity Read ↗

The NIMA kinase: a mitotic regulator in Aspergillus nidulans and vertebrate cells.Semantic proximity Read ↗

A pre-start checkpoint preventing mitosis in fission yeast acts independently of p34cdc2 tyrosine phosphorylation.Semantic proximity Read ↗

CDC25B phosphorylation by Aurora-A occurs at the G2/M transition and is inhibited by DNA damage.Semantic proximity Read ↗

Roles of the mitotic inhibitors Wee1 and Mik1 in the G(2) DNA damage and replication checkpoints.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.