Article
The G2/M DNA damage checkpoint inhibits mitosis through Tyr15 phosphorylation of p34cdc2 in Aspergillus nidulans.
The EMBO journal - 2 Jan 1997
Ye X S, Fincher R R, Tang A, Osmani S A
Abstract excerpt
It is possible to cause G2 arrest in Aspergillus nidulans by inactivating either p34cdc2 or NIMA. We therefore investigated the negative control of these two mitosis-promoting kinases after DNA damage. DNA damage caused rapid Tyr15 phosphorylation of p34cdc2 and transient cell cycle arrest but ha...
Topics
- Aspergillus nidulans
- CDC2 Protein Kinase
- Cell Cycle Proteins
- DNA Damage
- DNA Repair
- DNA, Fungal
- G2 Phase
- Methyl Methanesulfonate
- Mitosis
- Mutagens
- Mutation
- NIMA-Related Kinase 1
- NIMA-Related Kinases
- Phosphorylation
- Protein Serine-Threonine Kinases
- Tyrosine
- Ultraviolet Rays