A single p34cdc2 protein kinase (encoded by nimXcdc2) is required at G1 and G2 in Aspergillus nidulans.

doi:10.1242/jcs.107.6.1519

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Article

A single p34cdc2 protein kinase (encoded by nimXcdc2) is required at G1 and G2 in Aspergillus nidulans.

Journal of cell science - 1 Jun 1994

Osmani A H, van Peij N, Mischke M, O'Connell M J, Osmani S A

Abstract excerpt

We have cloned and sequenced a homolog of cdc2 from Aspergillus nidulans that can complement the Schizosaccharomyces pombe cdc2-33 mutation. The gene was deleted and is required for continued nuclear DNA replication but not for mitochondrial DNA replication. Three different temperature-sensitive...

Topics

Amino Acid Sequence
Animals
Antibodies
Aspergillus nidulans
Base Sequence
CDC2 Protein Kinase
Cyclins
DNA Replication
DNA, Fungal
Fungal Proteins
Genes, Fungal
Genetic Complementation Test

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Interphase

Male

Molecular Sequence Data

Phenotype

Rabbits

Schizosaccharomyces

Source

Open in PubMed

Identifiers

PMID: 7962194
DOI: 10.1242/jcs.107.6.1519

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-7962194-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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A single p34cdc2 protein kinase (encoded by nimXcdc2) is required at G1 and G2 in Aspergillus nidulans.PMID 7962194Read ↗

Parallel activation of the NIMA and p34cdc2 cell cycle-regulated protein kinases is required to initiate mitosis in A. nidulans.Semantic proximity Read ↗

The NIMA kinase: a mitotic regulator in Aspergillus nidulans and vertebrate cells.Semantic proximity Read ↗

Essential roles for calcium and calmodulin in G2/M progression in Aspergillus nidulans.Semantic proximity Read ↗

The NIMA protein kinase is hyperphosphorylated and activated downstream of p34cdc2/cyclin B: coordination of two mitosis promoting kinases.Semantic proximity Read ↗

Expression of the noncatalytic domain of the NIMA kinase causes a G2 arrest in Aspergillus nidulans.Semantic proximity Read ↗

Evidence for a NIMA-like mitotic pathway in vertebrate cells.Semantic proximity Read ↗

The protein kinase Cdr2, related to Nim1/Cdr1 mitotic inducer, regulates the onset of mitosis in fission yeast.Semantic proximity Read ↗

BIMAAPC3, a component of the Aspergillus anaphase promoting complex/cyclosome, is required for a G2 checkpoint blocking entry into mitosis in the absence of NIMA function.Semantic proximity Read ↗

The G2/M DNA damage checkpoint inhibits mitosis through Tyr15 phosphorylation of p34cdc2 in Aspergillus nidulans.Semantic proximity Read ↗

Two S-phase checkpoint systems, one involving the function of both BIME and Tyr15 phosphorylation of p34cdc2, inhibit NIMA and prevent premature mitosis.Semantic proximity Read ↗

Nik1: a Nim1-like protein kinase of S. cerevisiae interacts with the Cdc28 complex and regulates cell cycle progression.Semantic proximity Read ↗

PINA is essential for growth and positively influences NIMA function in Aspergillus nidulans.Semantic proximity Read ↗

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