Article
Essential roles for calcium and calmodulin in G2/M progression in Aspergillus nidulans.
The Journal of cell biology - 1 May 1993
Lu K P, Osmani S A, Osmani A H, Means A R
Abstract excerpt
nimT encodes a protein in Aspergillus nidulans that is required for tyrosine dephosphorylation of p34cdc2 and has a strong homology to cdc25-type proteins. Conditional mutation of nimT (nimT23 mutation) arrests cells in G2 at the restrictive temperature. After release of the temperature-sensitive nimT23 block, p34cdc2 undergoes tyrosine dephosphorylation and we showed that as cells entered mitosis, a rapid...
Topics
- Aspergillus nidulans
- CDC2 Protein Kinase
- Calcium
- Calmodulin
- Enzyme Activation
- G2 Phase
- Maturation-Promoting Factor
- Mitosis
- Mutation
- Phosphorylation
- Tyrosine
