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Article

Cdc2 tyrosine phosphorylation is not required for the S-phase DNA damage checkpoint in fission yeast.

Cell cycle (Georgetown, Tex.) - 1 Nov 2006

Kommajosyula Naveen, Rhind Nicholas

Abstract excerpt

The S-phase DNA damage checkpoint slows replication when damage occurs during S phase. Cdc25, which activates Cdc2 by dephosphorylating tyrosine-15, has been shown to be a downstream target of the checkpoint in metazoans, but its role is not clear in fission yeast. The dephosphorylation of Cdc2 has been assumed not to play a role in S-phase regulation because cells replicate in the absence of Cdc25, demonstrating...

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Identifiers

PMID: 17102632
DOI: 10.4161/cc.5.21.3423
PMCID: PMC2562503

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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