The NIMA protein kinase is hyperphosphorylated and activated downstream of p34cdc2/cyclin B: coordination of two mitosis promoting kinases.

doi:10.1002/j.1460-2075.1995.tb07079.x

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Article

The NIMA protein kinase is hyperphosphorylated and activated downstream of p34cdc2/cyclin B: coordination of two mitosis promoting kinases.

The EMBO journal - 1 Mar 1995

Ye X S, Xu G, Pu R T, Fincher R R, McGuire S L, Osmani A H, Osmani S A

Abstract excerpt

Initiation of mitosis in Aspergillus nidulans requires activation of two protein kinases, p34cdc2/cyclin B and NIMA. Forced expression of NIMA, even when p34cdc2 was inactivated, promoted chromatin condensation. NIMA may therefore directly cause mitotic chromosome condensation. However, the mitosis-promoting function of NIMA is normally under control of p34cdc2/cyclin B as the active G2 form of NIMA is...

Topics

Amino Acid Sequence
Aspergillus nidulans
Base Sequence
CDC2 Protein Kinase
Cell Cycle Proteins
Chromatin
Cyclins
Ethers, Cyclic
G2 Phase
Mitosis
Models, Biological

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Molecular Sequence Data

Mutation

NIMA-Related Kinase 1

NIMA-Related Kinases

Okadaic Acid

Phosphoprotein Phosphatases

Phosphoproteins

Source

Open in PubMed Open full text

Identifiers

PMID: 7889944
DOI: 10.1002/j.1460-2075.1995.tb07079.x
PMCID: PMC398170

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-7889944-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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The NIMA protein kinase is hyperphosphorylated and activated downstream of p34cdc2/cyclin B: coordination of two mitosis promoting kinases.PMID 7889944Read ↗

The NIMA kinase: a mitotic regulator in Aspergillus nidulans and vertebrate cells.Semantic proximity Read ↗

Parallel activation of the NIMA and p34cdc2 cell cycle-regulated protein kinases is required to initiate mitosis in A. nidulans.Semantic proximity Read ↗

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Expression of the noncatalytic domain of the NIMA kinase causes a G2 arrest in Aspergillus nidulans.Semantic proximity Read ↗

Two S-phase checkpoint systems, one involving the function of both BIME and Tyr15 phosphorylation of p34cdc2, inhibit NIMA and prevent premature mitosis.Semantic proximity Read ↗

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A single p34cdc2 protein kinase (encoded by nimXcdc2) is required at G1 and G2 in Aspergillus nidulans.Semantic proximity Read ↗

Cell cycle regulation by the NEK family of protein kinasesSemantic proximity Read ↗

Role of the cell-cycle-regulated NIMA protein kinase during G2 and mitosis: evidence for two pathways of mitotic regulation.Semantic proximity Read ↗

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