Article
Two S-phase checkpoint systems, one involving the function of both BIME and Tyr15 phosphorylation of p34cdc2, inhibit NIMA and prevent premature mitosis.
The EMBO journal - 15 Jul 1996
Ye X S, Fincher R R, Tang A, O'Donnell K, Osmani S A
Abstract excerpt
We demonstrate that there are at least two S-phase checkpoint mechanisms controlling mitosis in Aspergillus. The first responds to the rate of DNA replication and inhibits mitosis via tyrosine phosphorylation of p34cdc2. Cells unable to tyrosine phosphorylate p34cdc2 are therefore viable but are...
Topics
- Aspergillus nidulans
- Base Sequence
- CDC2 Protein Kinase
- Cell Cycle Proteins
- DNA
- DNA Primers
- Fungal Proteins
- Hydroxyurea
- Mitosis
- Molecular Sequence Data
- Mutation
- NIMA-Related Kinase 1