Article
Checkpoint defects leading to premature mitosis also cause endoreplication of DNA in Aspergillus nidulans.
Molecular biology of the cell - 1 Nov 1999
De Souza C P, Ye X S, Osmani S A
Abstract excerpt
The G2 DNA damage and slowing of S-phase checkpoints over mitosis function through tyrosine phosphorylation of NIMX(cdc2) in Aspergillus nidulans. We demonstrate that breaking these checkpoints leads to a defective premature mitosis followed by dramatic rereplication of genomic DNA. Two additional checkpoint functions, uvsB and uvsD, also cause the rereplication phenotype after their mutation allows premature...
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