Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

A pre-start checkpoint preventing mitosis in fission yeast acts independently of p34cdc2 tyrosine phosphorylation.

The EMBO journal - 15 Jun 1995

Hayles J, Nurse P

Abstract excerpt

We have monitored the tyrosine (Y15) phosphorylated and dephosphorylated forms of p34cdc2 from Schizosaccharomyces pombe as cells proceed through the cell cycle. Y15 is dephosphorylated in G1 before start and becomes phosphorylated only after cells pass start and enter late G1. This transition is associated with a switch from one checkpoint which restrains mitosis in pre-start G1, by a mechanism independent from...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cyclins
Share to Fungal Proteins
Share to Mitosis

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Mutation

Share to Phosphorylation

Share to Schizosaccharomyces

Share to Temperature

Share to Tyrosine

Source

Open in PubMed Open full text

Identifiers

PMID: 7796804
DOI: 10.1002/j.1460-2075.1995.tb07276.x
PMCID: PMC398394

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

A pre-start checkpoint preventing mitosis in fission yeast acts independently of p34cdc2 tyrosine phosphorylation.PMID 7796804Read ↗

Full activation of p34CDC28 histone H1 kinase activity is unable to promote entry into mitosis in checkpoint-arrested cells of the yeast Saccharomyces cerevisiae.Semantic proximity Read ↗

The chk1 pathway is required to prevent mitosis following cell-cycle arrest at 'start'.Semantic proximity Read ↗

Phosphorylation at Thr167 is required for Schizosaccharomyces pombe p34cdc2 function.Semantic proximity Read ↗

Cdc2 tyrosine phosphorylation is not required for the S-phase DNA damage checkpoint in fission yeast.Semantic proximity Read ↗

The Schizosaccharomyces pombe cdc14 gene is required for septum formation and can also inhibit nuclear division.Semantic proximity Read ↗

Complementation of the mitotic activator, p80cdc25, by a human protein-tyrosine phosphatase.Semantic proximity Read ↗

The fission yeast cdc18+ gene product couples S phase to START and mitosis.Semantic proximity Read ↗

Temporal order of S phase and mitosis in fission yeast is determined by the state of the p34cdc2-mitotic B cyclin complex.Semantic proximity Read ↗

Cdc18p can block mitosis by two independent mechanisms.Semantic proximity Read ↗

Analysis of the role of phosphorylation in fission yeast Cdc13p/cyclinB function.Semantic proximity Read ↗

Regulation of cdc2 activity in Schizosaccharomyces pombe: the role of phosphorylation.Semantic proximity Read ↗

Mutations of p34cdc2 phosphorylation sites induce premature mitotic events in HeLa cells: evidence for a double block to p34cdc2 kinase activation in vertebrates.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.