In vitro detection of the MDR phenotype in rat myocardium: use of PCR, [3H]daunomycin and MDR reversing agents.

doi:10.1097/00001813-199611000-00003

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Article

In vitro detection of the MDR phenotype in rat myocardium: use of PCR, [3H]daunomycin and MDR reversing agents.

Anti-cancer drugs - 1 Nov 1996

Cayre A, Moins N, Finat-Duclos F, Maublant J, Albuisson E, Verrelle P

Abstract excerpt

A decrease in the intracellular drug concentration in resistant cells as compared to sensitive cells is one of the characteristics of the MDR phenotype. P-glycoprotein (Pgp) is thought to be responsible for an active efflux of some lipophilic drugs such as anthracyclines. Anthracyclines such as daunomycin are highly effective anticancer agents but induce a well-described, while incompletely explained, cardiac...

Topics

ATP Binding Cassette Transporter, Subfamily B, Member 1
Animals
Animals, Newborn
Antibiotics, Antineoplastic
Cells, Cultured
Daunorubicin
Electrophoresis, Polyacrylamide Gel
Genes, MDR
Myocardium
Phenotype
Polymerase Chain Reaction
Rats
Rats, Wistar

Source

Open in PubMed

Identifiers

PMID: 8991186
DOI: 10.1097/00001813-199611000-00003

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