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Article

Overexpression of P-glycoprotein but not its mRNA in multidrug resistant cells selected with hydroxyrubicin.

Anticancer research - 1 Jan 2000

Zhao J Y, Savaraj N, Song R, Priebe W, Kuo M T

Abstract excerpt

Previous studies have revealed that cultured cells treated with lipophilic natural products containing aromatic rings and basic amino group usually yielded multidrug resistant (MDR) variants. These MDR cells overexpress P-glycoprotein (P-gp), most often due to gene amplification or transcriptional activation of mdr/P-gp genes. Doxorubicin (Dox) is an anthracycline that belongs to this group of compounds. To...

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PMID: 7531410

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