Article
Overexpression of P-glycoprotein but not its mRNA in multidrug resistant cells selected with hydroxyrubicin.
Anticancer research - 1 Jan 2000
Zhao J Y, Savaraj N, Song R, Priebe W, Kuo M T
Abstract excerpt
Previous studies have revealed that cultured cells treated with lipophilic natural products containing aromatic rings and basic amino group usually yielded multidrug resistant (MDR) variants. These MDR cells overexpress P-glycoprotein (P-gp), most often due to gene amplification or transcriptiona...
Topics
- ATP Binding Cassette Transporter, Subfamily B, Member 1
- Amino Acid Sequence
- Animals
- Blotting, Western
- CHO Cells
- Clone Cells
- Cricetinae
- DNA, Complementary
- Doxorubicin
- Drug Resistance, Multiple
- Epirubicin
- Gene Expression
- HeLa Cells
- Humans
- Immunohistochemistry
- Molecular Sequence Data
- Nucleic Acid Hybridization
- Phenotype