Article
Effects of R-enantiomer (GR66234A) and L-enantiomer (GR66235A) of telupidine, a new dihydropyridine derivative, on cell lines displaying the multidrug resistant phenotype.
Haematologica - 1 Jan 2000
Tolomeo M, Gancitano R A, Musso M, Porretto F, Perricone R, Abbadessa V, Cajozzo A
Abstract excerpt
BACKGROUND: Many dihydropyridine analogues with calcium channel blocker activity are able to reverse multidrug resistance (MDR). We studied the daunorubicin resistance reversing activity of the R enantiomer (GR66234A) and the L-enantiomer (GR66235 A) of teludipine, a new lipophilic calcium channel blocker synthesized by Glaxo. METHODS: The daunorubicin resistance reversing activity of the enantiomers of...
Topics
- Animals
- Calcium Channel Blockers
- Daunorubicin
- Dihydropyridines
- Drug Resistance, Multiple
- Humans
- Mice
- Phenotype
- Stereoisomerism
- Tumor Cells, Cultured