Article
Comparison of the kinetics of active efflux of 99mTc-MIBI in cells with P-glycoprotein-mediated and multidrug-resistance protein-associated multidrug-resistance phenotypes.
European journal of biochemistry - 15 Feb 1998
Vergote J, Moretti J L, de Vries E G, Garnier-Suillerot A
Abstract excerpt
The overexpression of two membrane glycoproteins, P-glycoprotein and multidrug-resistance protein (MRP1) is a major cause of resistance to chemotherapeutic agents in the treatment of human cancers. Both proteins confer a similar multidrug-resistant (MDR) phenotype. 99mTc-MIBI, a myocardial imagin...
Topics
- ATP Binding Cassette Transporter, Subfamily B, Member 1
- ATP-Binding Cassette Transporters
- Antibiotics, Antineoplastic
- Biological Transport
- Daunorubicin
- Drug Resistance, Multiple
- Humans
- Kinetics
- Membrane Potentials
- Multidrug Resistance-Associated Proteins
- Neoplasm Proteins
- Organotechnetium Compounds
- Phenotype