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Article

Reversal of drug sensitivity in MDR subline of P388 leukemia by gene-targeted antisense oligonucleotide.

Journal of pharmaceutical sciences - 1 Oct 1995

Nakashima E, Matsushita R, Negishi H, Nomura M, Harada S, Yamamoto H, Miyamoto K, Ichimura F

Abstract excerpt

We attempted to reverse multidrug resistance (MDR) by treatment with 25-mer antisense phosphorothioate oligonucleotide. The phosphorothioate analogs, the sequences of which are sense or antisense to the initiation codon of mouse mdr1 mRNA, were tested against murine leukemic P388/S and adriamycin-resistant P388/ADR cell lines. A weak inhibitory effect on the growth of P388/S and P388/ADR cells was observed at a...

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Identifiers

PMID: 8801335
DOI: 10.1002/jps.2600841012

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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