Article
Reversal of drug sensitivity in MDR subline of P388 leukemia by gene-targeted antisense oligonucleotide.
Journal of pharmaceutical sciences - 1 Oct 1995
Nakashima E, Matsushita R, Negishi H, Nomura M, Harada S, Yamamoto H, Miyamoto K, Ichimura F
Abstract excerpt
We attempted to reverse multidrug resistance (MDR) by treatment with 25-mer antisense phosphorothioate oligonucleotide. The phosphorothioate analogs, the sequences of which are sense or antisense to the initiation codon of mouse mdr1 mRNA, were tested against murine leukemic P388/S and adriamycin-resistant P388/ADR cell lines. A weak inhibitory effect on the growth of P388/S and P388/ADR cells was observed at a...
Topics
- ATP Binding Cassette Transporter, Subfamily B, Member 1
- Animals
- Antineoplastic Agents
- Base Sequence
- Calcium Channel Blockers
- Dose-Response Relationship, Drug
- Doxorubicin
- Drug Resistance, Multiple
- Drug Resistance, Neoplasm
- Drug Screening Assays, Antitumor
- Female
- Leukemia P388