Article
A comparison of rhodamine 123 accumulation and efflux in cells with P-glycoprotein-mediated and MRP-associated multidrug resistance phenotypes.
European journal of cancer (Oxford, England : 1990) - 1 Jan 1994
Twentyman P R, Rhodes T, Rayner S
Abstract excerpt
Rhodamine 123 (Rh123) is a fluorescent dye which locates in the mitochondria of cells. It is a substrate for P-glycoprotein (Pgp) and can, therefore, be used as a molecular probe in studies of the multidrug resistance (MDR) phenotype. However, not all MDR cells overexpress Pgp. In some, the MDR phenotype is associated with expression of an alternative transporter molecule, the multidrug resistance-associated...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.