Article
A comparison of rhodamine 123 accumulation and efflux in cells with P-glycoprotein-mediated and MRP-associated multidrug resistance phenotypes.
European journal of cancer (Oxford, England : 1990) - 1 Jan 1994
Twentyman P R, Rhodes T, Rayner S
Abstract excerpt
Rhodamine 123 (Rh123) is a fluorescent dye which locates in the mitochondria of cells. It is a substrate for P-glycoprotein (Pgp) and can, therefore, be used as a molecular probe in studies of the multidrug resistance (MDR) phenotype. However, not all MDR cells overexpress Pgp. In some, the MDR p...
Topics
- ATP Binding Cassette Transporter, Subfamily B, Member 1
- Animals
- Cyclosporine
- Drug Resistance, Multiple
- Flow Cytometry
- Hot Temperature
- Humans
- Lung Neoplasms
- Mammary Neoplasms, Animal
- Mice
- Mitochondria
- Phenotype
- Rhodamine 123
- Rhodamines
- Time Factors
- Tumor Cells, Cultured